All experimental protocols were approved by the university of queensland animal experimentation ethics committee, under the guidelines of the national health and medical research council of australia. Taurine prevents hypertension and increases exercise capacity. The role of ang ii in fructoseinduced hypertension is supported by the work of erlich and rosenthal, who demonstrated that three different angiotensinconverting enzyme ace inhibitors are able to normalize bp in fructosefed rats. Chapter 8 effect of tender coconut water in high fructose fed. More recently, increased formation of reactive oxygen species and elevated levels of uric acid have been reported to contribute to fructose induced hypertension. Fructoseinduced hypertension in rats is concentration. Johnson rj, segal ms, sautin y, et al potential role of sugar fructose in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Original article mangiferin diminishes chronic fructose. Attenuation of fructoseinduced hypertension in rats by. The rats were divided randomly into six groups of six rats in each. Reaven summary to determine if hypertension could be produced in normal rats by feeding them a.
Therapeutic effects of tender coconut water on oxidative. Pdf fructoseinduced insulin resistance and hypertension. Further studies will be required to assess the contribution of insulin receptor abnormalities to the development of the hypertensive response to chronic fructose feeding in rats. The rats were kept in a laboratory animal unit with a 12 hr lightdark cycle.
Group 1 control rats group 2 high fructose fed hypertensive rats. Hypoglycemic, hypolipidemic and antioxidant effects of. A similar effect by concanavalin a suggests that the effect may be. Regulation of adipose differentiation by fructose and glut5 li du. Effect of myricetin on blood pressure and metabolic. Lactobacillus plantarum k68 isolated from futsai and fruitvegetable ferment fvf have been tested for antidiabetic, antiinflammatory, and antioxidant properties in a rat model of insulin resistance, induced by chronic high fat fructose diet. Pdf dietary vitamin e and c supplementation prevents. Mitigation of insulin resistance by mangiferin in a rat model. The results showed that treatment of wistarkyoto rats with mangiferin 15 mgkg, once daily, by oral gavage for 7 weeks inhibited chronic liquid fructose consumptioninduced increases in plasma insulin concentrations at the baseline and during oral glucose tolerance test ogtt, and the homeostasis model assessment of insulin resistance index. In four experiments, diet induced obese rats were randomized to diets containing either lactalbumin or lactoferrin at low 20% kcal or high 40% kcal doses, and inulin at low 7. The administration of a single intraperitoneal injection of 50 mgkg body weight of alloxan monohydrate induced diabetes in rats after 72 h. At the end of 8 weeks, serum glucose, insulin, cholesterol, triglyceride and cardiovascular risk indices, as well as insulin resistance were significantly increased in fructose fed rats. Supplementation of lactobacillus plantarum k68 and fruit. Effect of longterm highprotein diet on insulin secretion in.
We selected sixty wister rats groups of animals each, including the control group c, and four diabetic groups control d and groups treated with insulin i, honey h, and insulin plus honey i. Papers of particular interest, published recently, have been highlighted as. Effect of dietary chloride intake on fructoseinduced hypertension, and blood and urine chemical analysis in rat. Enteromorphaflexuosa improves insulin sensitivity and. Nebivolol improves insulin sensitivity in highsucrose diet. Rats who had their drinking water replaced with an 8%. Control con, which received a normal salt diet and.
Theraputic effects of rhein on the insulin resistance in. A high fructosefed rat model of insulinresistance syndrome has a metabolic profile very similar to that of the human x syndrome, which is associated with a high incidence of cardiovascular disease and hypertension. Hsieh ps1, tai yh, loh ch, shih kc, cheng wt, chu ch. In conclusion, taurine may ameliorate fructose induced hypertension in rats by preventing an increase in intracellular free calcium concentration. The present study investigated whether chronic treatment with purified tartary buckwheat flavonoids fraction tbf prevents the development of hypertension via improving vascular insulin sensitivity and r. Jun 27, 2012 paraoxonase 1 pon1 is a hdlassociated esteraselactonase and its activity is inversely related to the risk of cardiovascular diseases. We have examined the effect of myricetin 100 and 300mgkg, p. The blood pressurelowering effect of taurine appeared to be independent from its effect on glucose and lipid metabolism in this model. Salt overload in fructosefed insulinresistant rats. Cellular mechanisms of insulin resistance in rats with. High dietary salt decreases antioxidant defenses in the liver.
Fructose feeding can also cause insulin resistance and hyperinsulinemia in normal r a t s. Aug 02, 2008 effect of dietary chloride intake on fructose induced hypertension, and blood and urine chemical analysis in rat. Several studies showed that ms induced by high fat, higined sugar diet is accompanied by oxidative stress and nitric oxide synthase dysregulation 11. The use of 10% fructose in drinking water, which is equivalent to a diet containing 4857% by calories fructose, for one week or longer appeared to be most suitable for rapid production of fructoseinduced hypertension. Jun 18, 2009 hsieh ps, tai yh, loh ch, shih kc, cheng wt, chu ch 2005 functional interaction of at1 and at2 receptors in fructoseinduced insulin resistance and hypertension in rats. We recently showed that a high fructose diet containing vegetable oil but a normal sodiumpotassium ratio induced mild insulin resistance with decreased insulin receptor substrate1 tyrosine phosphorylation in the liver and muscle of normal rats. Systolic blood pressure increased significantly in rats on increased dietary fructose intake for 5 weeks. Effect of longterm highprotein diet on insulin secretion in diet induced obesity rats the longterm effect of high the longterm effect of highprotein diet on glucose metabolism and insulin secretion in obese individuals remains controversial. Pdf antihypertensive effect of abelmoschus esculentus. Mangiferin diminishes chronic fructose overconsumption induced cardiac fibrosis in spontaneous hypertension rats ling yao 1, chunli li2, ting chen1, weiguo cao, johji yamahara3, yuhao li1,4, yunmei zhang5, jianwei wang1 1chongqing key laboratory of traditional chinese medicine for prevention and cure of metabolic diseases. Bhanot s, mcneill j and bryerash m 2018 vanadyl sulfate prevents fructoseinduced hyperinsulinemia and hypertension in rats. Fructose induced insulin resistance and hypertension in rats ishun hwang, helen ho, brian b. Dietary lipoic acid supplementation prevents fructoseinduced hypertension in rats article in nutrition metabolism and cardiovascular diseases 106.
Troxerutin chronic treatment protects against fructose. Fructose feeding induces a rise in blood pressure in normal rats and is associated with insulin resistance, hyperinsulinemia, and hypertriglyceridemia. The fasting blood glucose levels in alloxaninduced diabetic rats were 21. Zincfree insulin elicited a reduction in the potassium conductance of muscle fibers from potassiumdepleted muscle, which led to depolarization, blockage of actionpoteintial mechanism, and paralysis. Protective effect of rosiglitazone, quercetin, and their. Rats fed a high fructose diet represent an animal model for insulin resistance and hypertension. College of pharmacy, navarangpura, ahmedabad 380 009, india received 8 september 2004. In conclusion, this study indicates a possible cellular mechanism for the reduced sensitivity to insulin present in rats with fructose induced hypertension. These changes are proposed as the mechanism of insulin induced paralysis in patients with hypokalemic periodic paralysis. Alteration of muscle fiber composition linking to insulin.
Dietary lipoic acid supplementation prevents fructose induced hypertension in rats. A highfructose diet induces insulin resistance but not blood. Effect of pioglitazone on lname induced hypertension in. Grape seed extract supplementation prevents highfructose. Diabetes mellitus was induced chemically by intraperitoneal administration of stz 40 mgkg b. The roles of nitric oxide, impaired endotheliumdependent relaxation and sex hormones in the pathogenesis of the fructose fed induced hypertensive rats have also been highlighted. Protective effect of rosiglitazone, quercetin, and their combination on fructoseinduced metabolic syndrome in rats amira m aboyoussef department of pharmacology and toxicology, faculty of pharmacy, beni suef university, beni suef, egypt.
The mechanisms underlying fructoseinduced hypertension. The aim of this study was to examine the role of muscle fiber composition in insulin resistance and the effect of a calcium channel antagonist on insu. Pharmacological inhibition of soluble epoxide hydrolase. Functional interaction of at1 and at2 receptors in fructose. Regulation of adipose differentiation by fructose and.
Theraputic effects of rhein on the insulin resistance in liver of diabetic rats induced by streptozotocin in this study, we investigated in this study, we investigated the effects of rehin on the insulin sensitivity in low dose stz induced diabetic rats and the possible mechanisms. Fructose induced insulin resistance and hypertension in rats. Thus, the metabolic changes associated with fructoseinduced hypertension are unlikely to be secondary to an increase in sympathetic activity. Adult male fischer rats were initially divided into two groups. The addition of clonidine to the drinking water inhibited fructoseinduced hypertension, but not the increase in plasma insulin or triglyceride concentration seen in fructosefed rats. Dietary lactalbumin and lactoferrin interact with inulin to. Dietary lipoic acid supplementation prevents fructoseinduced. The rats were divided into 4 groups of six each and fed the following diet.
Animals male sprague dawley rats weighing between 150170 g were used for the study. Vascular insulin resistance and oxidative stress contribute to endothelial dysfunction and hypertension. We investigated the e ects of insulin and honey as antioxidants to prevent the hippocampal cell death in streptozotocin induced diabetic rats. Male wistar rats 89 weeks old were obtained from the university of queensland biological resources. Functional interaction of at1 and at2 receptors in fructose induced insulin resistance and hypertension in rats. Oral taurine supplementation prevents fructoseinduced.
Throughout the experiment, room temperature was maintained at 25. Antihypertensive effects of tartary buckwheat flavonoids by. Effect of insulin treatment on smooth muscle contractility. Heaney, regulation of adipose differentiation by fructose and glut5, molecular endocrinology, volume 26, issue. The aim of the present study was to evaluate the effect of a highsalt diet on serum pon1 activity in fructose fed insulinresistant rats. Fructoseinduced insulin resistance and hypertension in rats. Bhanot s and mcneill j 2018 vanadyl sulfate lowers plasma insulin and blood pressure in spontaneously hypertensive rats. Discussion the present study showed that the intensity of fructoseinduced hypertension in rats was related to the concentration of fructose solution used and to the duration of fructose treatment. The present study investigates the effect of pioglitazone treatment on blood pressure, vascular reactivity and antioxidant enzymes in lname induced hypertension in normal and stzdiabetic rats.
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